Titanium® 5 L5 HB contains desiccated Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine and a bacterin diluent (Lepto 5 HB). Titanium 5® L5 HB is a multiantigenic modified live vaccine to be used as an aid in the preventio of disease caused by infectious bovine rhinotracheitis virus (IBR), bovine virus diarrhea virus (BVD), bovine parainfluenza3 virus (PI3), and bovine respiratory syncytial virus (BRSV) and a bacterin to aid in the prevention of disease caused by Leptospira borgpetersenii serovar hardjo-bovis and Leptospira canicola, Leptospira grippotyphosa, Leptospira hardjo, Leptospira icterohaemorrhagiae, and Leptospira pomona.The five viral antigens are combined in the proper ratio, stabilized and desiccated int one cake. The desiccated viral fractions are rehydrated for use with a specially processed liquid Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin, Lepto 5.The desiccated fraction contains no bovine serum, virtually eliminating extraneous virus contamination and possible allergic reactions. Controlled tests conducted in our laboratory demonstrated that animals receiving a 10x dose did not shed BRSV or PI3 viruses. Control animals, housed with vaccinates, remained seronegative throughout the testing period.